Synthesis, Characterization and Application of Chitosan-Coated Magnetite Nanoparticles in Drug Delivery
D.Balaji1, M.Vijay Albert William2, C.Sarala Rubi3
1D.Balaji*, Department of Electronics & Communication Engineering, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Chennai, Tamil Nadu, India.
2M.Vijay Albert William, Department of Electronics & Communication Engineering, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Chennai, Tamil Nadu, India.
3C.Sarala Rubi, Department of Physics, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Chennai, Tamil Nadu, India.
Manuscript received on February 06, 2020. | Revised Manuscript received on February 10, 2020. | Manuscript published on February 30, 2020. | PP: 1203-1126 | Volume-9 Issue-3, February, 2020. | Retrieval Number: B4665129219 /2020©BEIESP | DOI: 10.35940/ijeat.B4665.029320
Open Access | Ethics and Policies | Cite | Mendeley
© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Abstract: Magnetite nanoparticles were used extensively for various applications. In the present study, magnetite nanoparticles were synthesized and characterized by atomic force microscopy (AFM). AFM images showed that the obtained particles were perfectly spherical. Functionality is afforded to these magnetite nanoparticles by adding biocompatible polymer chitosan during the synthesis. AFM phase image clearly showed that the magnetite core is encapsulated with the polymeric shell. Fourier-transform infrared spectroscopy (FTIR) study showed the chitosan absorption on Fe2O3 nanoparticle surface. The drug sulphamethoxazole was loaded over magnetite nanoparticles and the encapsulation efficiency of drug was calculated at different concentrations of magnetite. The encapsulation efficiency increases with increase in the concentration of magnetite. Thus, an attempt was made in synthesizing drug loaded biopolymer magnetite nanoparticles suitable for targeted drug delivery.
Keywords: Nanoparticle: Chitosan; AFM; Coating; Polymer.