A nti bacterial , Antioxidant and A nti Inflammatory P otential of the Different Extracts of Holoptelia Integrifolia
T. Mohammad Munawar1, D. Muralidhara Rao2, P. Subramanyam3

1Dr.T. Mohammad Munawar*, Department of Biological and Chemical Engineering, Mekelle Institute of Technology (MIT), Mekelle University, Ethiopia.
2Dr. D.Muralidhara Rao, Department of Biotechnology, Sree  Kroshnadevarya University, Anantapuramu, Andhra Pradesh, India.
3Dr. P. Subramanyam, Department of Botany, Loyola Degree College, Pulivendula, Andhra Pradesh, India.
Manuscript received on November 10, 2019. | Revised Manuscript received on December 22, 2019. | Manuscript published on December 30, 2019. | PP: 5236-5240 | Volume-9 Issue-2, December, 2019. | Retrieval Number: A9584109119/2019©BEIESP | DOI: 10.35940/ijitee.A9584.119119
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© The Authors. Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Abstract: Medicinal plants are play significant impact in the personal medicine for most of the people all over the world as an alternative live saving medicines and most of their medicinal properties are well known for anticancer activity. The different extracts of Holoptelea integrifolia (H. integrifolia) leaves, stem bark and fruits were studied as a potent natural source of antimicrobial, antioxidant and wound healing potential. This work was carried out to evaluate antimicrobial, antioxidant and anti-inflammatory activity of different extracts of H. integrifolia. The antimicrobial activity of the H. integrifolia ethanolic extract was studied against five fungal and bacterial strains by utilizing the agar well diffusion method and MIC. Among several strain, the ethanolic extract of fruit has shown higher antimicrobial inhibition zone as 9.25-16 mm compare to other two extracts of stem and leaves as 10- 13.25 mm and 6-10.2 mm respectively. The antioxidant activities for different extract were also determined by DPPH free radical assay, Hydroxyl Radical Scavenging and Nitric Oxide Radical Scavenging Activity method. The anti-inflammatory activity also estimated basedon formalin induced paw edema method on Wistar albino rats. The different extracts of leaves, stem bark and fruit parts of Holoptelea integrifolia were estimated for in vivo anti-inflammatory activity against the animal model of female Wistar albino rats. The results of anti-inflammatory activity revealed that the Ethanol extracts showed vital and dose-dependent anti-inflammatory effects. Our findings revealed that aerial parts of H. integrifolia contais potential antimicrobial, antioxidant and anti-inflammatory compounds, which expose the medicinal potential of the selected plant could be a significant drug candidates against microbial, oxidative and inflammation-related pathological processes as a future alternative medicine.
Keywords: Holoptelea integrifolia, Microbial inhibition concentration, DPPH, Hydroxyl Radical Scavenging, Nitric Oxide Radical Scavenging, Anti-inflammatory.